John V Fahy Selected Research

Immunoglobulin E (IgE)

10/2019	An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
1/2019	The Cytokines of Asthma.
1/2019	Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids.
1/2017	Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma.
7/2013	A qPCR-based metric of Th2 airway inflammation in asthma.
9/2012	Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.
1/2012	Cluster analysis of obesity and asthma phenotypes.
5/2011	The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose.
9/2009	T-helper type 2-driven inflammation defines major subphenotypes of asthma.
6/2006	Anti-IgE: lessons learned from effects on airway inflammation and asthma exacerbation.

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John V Fahy Research Topics

Disease

87	Asthma (Bronchial Asthma) 11/2022 - 02/2002
39	Inflammation (Inflammations) 01/2022 - 02/2002
11	Eosinophilia 01/2019 - 12/2003
5	Respiratory Hypersensitivity 01/2017 - 09/2004
4	Virus Diseases (Viral Diseases) 01/2022 - 01/2011
4	Chronic Obstructive Pulmonary Disease (COPD) 01/2018 - 03/2010
3	COVID-19 01/2022 - 01/2021
3	Pneumonia (Pneumonitis) 01/2022 - 04/2016
3	Body Weight (Weight, Body) 01/2019 - 01/2012
3	Fibrosis (Cirrhosis) 02/2011 - 10/2007
3	Hyperplasia 10/2007 - 08/2002
2	Hemorrhage 01/2022 - 11/2021
2	Lung Injury 01/2022 - 11/2021
2	Cystic Fibrosis (Mucoviscidosis) 01/2022 - 11/2006
2	Obesity 01/2022 - 01/2021
2	Hypertension (High Blood Pressure) 01/2021 - 01/2016
2	Anaphylaxis (Anaphylactic Shock) 10/2019 - 05/2011
2	Infections 04/2016 - 04/2014
2	Metaplasia 10/2009 - 10/2007
2	Hypertrophy 10/2006 - 08/2002
1	Atopic Dermatitis (Atopic Eczema) 01/2022
1	Immune System Diseases (Immune Disorders) 01/2022
1	Metabolic Diseases (Metabolic Disease) 01/2022

Drug/Important Bio-Agent (IBA)

32	Adrenal Cortex Hormones (Corticosteroids)IBA 11/2022 - 02/2002
15	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2007
14	CytokinesIBA 01/2022 - 06/2006
11	Immunoglobulin E (IgE)IBA 10/2019 - 09/2004
10	MucinsIBA 04/2016 - 12/2002
7	Bronchodilator Agents (Bronchodilators)IBA 11/2022 - 04/2005
7	Methacholine Chloride (Methacholine)FDA Link 07/2013 - 09/2004
6	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2021 - 04/2005
6	Interleukin-13IBA 01/2019 - 08/2005
5	GlucocorticoidsIBA 01/2020 - 10/2010
5	SteroidsIBA 01/2019 - 05/2002
5	PeriostinIBA 02/2014 - 10/2007
5	Salmeterol Xinafoate (Serevent)FDA Link 10/2010 - 04/2005
4	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 08/2005
4	Interleukin-6 (Interleukin 6)IBA 10/2020 - 01/2016
4	Interleukin-4 (Interleukin 4)IBA 01/2019 - 09/2004
3	Sulfhydryl Compounds (Thiols)IBA 01/2022 - 02/2015
3	AndrogensIBA 01/2021 - 04/2018
3	Triamcinolone (Aristocort)FDA Link 01/2021 - 01/2019
3	LigandsIBA 01/2021 - 07/2017
3	Tryptases (Tryptase)IBA 01/2020 - 05/2010
3	anti-IgE antibodiesIBA 10/2019 - 06/2006
3	Interleukin-5 (Interleukin 5)IBA 01/2019 - 09/2009
3	AllergensIBA 03/2018 - 10/2009
3	Proteins (Proteins, Gene)FDA Link 11/2016 - 05/2011
3	Albuterol (Salbutamol)FDA LinkGeneric 01/2013 - 10/2004
3	Peptide Hydrolases (Proteases)FDA Link 05/2010 - 06/2006
2	Cysteamine (Mercaptamine)FDA Link 01/2022 - 11/2021
2	AntioxidantsIBA 01/2022 - 11/2021
2	Antiviral Agents (Antivirals)IBA 01/2022 - 01/2021
2	Protein Isoforms (Isoforms)IBA 01/2021 - 01/2016
2	InterferonsIBA 01/2021 - 06/2012
2	AntibodiesIBA 01/2020 - 05/2011
2	Tiotropium Bromide (Spiriva)FDA Link 01/2019 - 10/2010
2	Serum Amyloid A Protein (Serum Amyloid A)IBA 01/2018 - 07/2017
2	RNA (Ribonucleic Acid)IBA 01/2018 - 01/2016
2	lipoxin A4IBA 01/2018 - 07/2017
2	AntigensIBA 01/2017 - 01/2011
2	Glycoproteins (Glycoprotein)IBA 04/2016 - 08/2009
2	Interleukin-33IBA 01/2016 - 01/2016
2	MicroRNAs (MicroRNA)IBA 12/2014 - 11/2012
2	SmokeIBA 04/2014 - 04/2007
2	Chloride Channels (Chloride Channel)IBA 02/2014 - 10/2007
2	Biological ProductsIBA 02/2011 - 12/2003
2	ChemokinesIBA 02/2011 - 06/2006
2	CollagenIBA 08/2010 - 08/2002
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 11/2009 - 03/2006
2	arginylarginine (Arg-Arg)IBA 11/2009 - 10/2004
2	Arginine (L-Arginine)FDA Link 11/2009 - 03/2006
2	ChitinasesIBA 07/2009 - 11/2008
2	Leukotriene Antagonists (Leukotriene Receptor Antagonists)IBA 04/2007 - 02/2007
2	Beclomethasone (Beclometasone)FDA Link 04/2007 - 02/2007
2	montelukast (Singulair)FDA Link 04/2007 - 02/2007
2	Omalizumab (Xolair)FDA Link 06/2006 - 09/2004
1	Glutathione Disulfide (GSSG)FDA LinkGeneric 01/2022
1	HeliumIBA 01/2022
1	AerosolsIBA 01/2022
1	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 01/2022
1	Glutathione (Reduced Glutathione)IBA 01/2022
1	Nitric Oxide Synthase (NO Synthase)IBA 01/2021
1	Androgen Receptors (Androgen Receptor)IBA 01/2021
1	AK002IBA 01/2020
1	Angiotensin-Converting Enzyme 2IBA 01/2020
1	Dehydroepiandrosterone SulfateIBA 01/2020
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2020
1	Serine Proteases (Serine Protease)IBA 01/2020
1	Muscarinic AntagonistsIBA 01/2019
1	Mometasone Furoate (Nasonex)FDA LinkGeneric 01/2019
1	Caspase 1 (ICE Protease)IBA 01/2019
1	InflammasomesIBA 01/2019
1	Expectorants (Mucolytics)IBA 11/2018
1	Gonadal Steroid Hormones (Sex Hormones)IBA 04/2018
1	Estradiol (Delestrogen)FDA LinkGeneric 04/2018

Therapy/Procedure

28	Therapeutics 01/2022 - 02/2002
2	Precision Medicine 01/2022 - 01/2021
1	Biological Therapy 01/2022
1	Immunotherapy 01/2022